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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:ibandronate drug pathway
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Accession:PW:0002000 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of ibandronate - a nitrogenous bisphosphonate drug used to treat bone diseases. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.

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ibandronate pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 ISO SMPDB SMP:00079 NCBI chrNW_004624855:3,177,402...3,199,634
Ensembl chrNW_004624855:3,176,171...3,199,705 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase ISO SMPDB SMP:00079 NCBI chrNW_004624862:4,995,836...5,022,395
Ensembl chrNW_004624862:4,995,720...5,020,850 		JBrowse link
G Ebp EBP cholestenol delta-isomerase ISO SMPDB SMP:00079 NCBI chrNW_004624893:340,843...346,560
Ensembl chrNW_004624893:341,129...347,717 		JBrowse link
G Fdft1 farnesyl-diphosphate farnesyltransferase 1 ISO SMPDB SMP:00079 NCBI chrNW_004624758:25,340,142...25,363,669
Ensembl chrNW_004624758:25,340,074...25,366,299 		JBrowse link
G Fdps farnesyl diphosphate synthase ISO SMPDB SMP:00079 NCBI chrNW_004624885:942,998...949,529
Ensembl chrNW_004624885:943,571...949,528 		JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 ISO SMPDB SMP:00079 NCBI chrNW_004624775:15,141,131...15,149,187 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO SMPDB SMP:00079 NCBI chrNW_004624951:681,559...711,476
Ensembl chrNW_004624951:682,178...711,474 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 ISO SMPDB SMP:00079 NCBI chrNW_004624759:11,826,793...11,847,111
Ensembl chrNW_004624759:11,826,876...11,847,111 		JBrowse link
G Hsd17b7 hydroxysteroid 17-beta dehydrogenase 7 ISO SMPDB SMP:00079 NCBI chrNW_004624826:1,260,133...1,287,565
Ensembl chrNW_004624826:1,260,223...1,283,741 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 ISO SMPDB SMP:00079 NCBI chrNW_004624775:9,806,482...9,879,265 JBrowse link
G Lipa lipase A, lysosomal acid type ISO SMPDB SMP:00079 NCBI chrNW_004624737:49,471...82,981
Ensembl chrNW_004624737:49,371...83,514 		JBrowse link
G LOC101724157 lanosterol 14-alpha demethylase ISO SMPDB SMP:00079 NCBI chrNW_004624809:1,080,427...1,110,802
Ensembl chrNW_004624809:1,080,656...1,100,254 		JBrowse link
G Lss lanosterol synthase ISO SMPDB SMP:00079 NCBI chrNW_004624745:31,301,648...31,325,283
Ensembl chrNW_004624745:31,306,807...31,325,199 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 ISO SMPDB SMP:00079 NCBI chrNW_004624758:11,629,824...11,644,071
Ensembl chrNW_004624758:11,629,007...11,644,263 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase ISO SMPDB SMP:00079 NCBI chrNW_004624746:905,919...911,591
Ensembl chrNW_004624746:905,757...911,591 		JBrowse link
G Mvk mevalonate kinase ISO SMPDB SMP:00079 NCBI chrNW_004624747:10,837,743...10,858,758
Ensembl chrNW_004624747:10,834,306...10,857,595 		JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like ISO SMPDB SMP:00079 NCBI chrNW_004624883:4,039,876...4,062,309
Ensembl chrNW_004624883:4,039,898...4,066,123 		JBrowse link
G Pmvk phosphomevalonate kinase ISO SMPDB SMP:00079 NCBI chrNW_004624885:2,544,136...2,552,591
Ensembl chrNW_004624885:2,543,862...2,553,237 		JBrowse link
G Sc5d sterol-C5-desaturase ISO SMPDB SMP:00079 NCBI chrNW_004624880:3,874,337...3,896,721 JBrowse link
G Soat1 sterol O-acyltransferase 1 ISO SMPDB SMP:00079 NCBI chrNW_004624771:2,992,752...3,055,842
Ensembl chrNW_004624771:2,994,696...3,055,916 		JBrowse link
G Sqle squalene epoxidase ISO SMPDB SMP:00079 NCBI chrNW_004624735:30,225,307...30,246,202
Ensembl chrNW_004624735:30,226,465...30,246,294 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 ISO SMPDB SMP:00079 NCBI chrNW_004624767:21,287,398...21,291,619
Ensembl chrNW_004624767:21,285,395...21,292,922 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3922
    drug pathway 349
      musculo-skeletal system drug pathway 53
        bisphosphonate drug pathway 22
          nitrogenous bisphosphonate drug pathway 22
            ibandronate drug pathway 22
              ibandronate pharmacodynamics pathway 22
              ibandronate pharmacokinetics pathway 0
paths to the root